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Metabolism Alprazolam is thoroughly metabolized in people, generally by cytochrome P450 3A4 (CYP3A4), to two big Energetic metabolites inside the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation levels of the two Energetic metabolites are below 4% with the guardian. The documented relative potencies in benzodiazepine rec